Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3–56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence stra...

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Autores principales: Meumann, Ella M, Anstey, Nicholas M, Currie, Bart J, Piera, Kim A, Baird, Robert, Sarovich, Derek S, Davis, Joshua S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602382/
https://www.ncbi.nlm.nih.gov/pubmed/31281860
http://dx.doi.org/10.1093/ofid/ofz263
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author Meumann, Ella M
Anstey, Nicholas M
Currie, Bart J
Piera, Kim A
Baird, Robert
Sarovich, Derek S
Davis, Joshua S
author_facet Meumann, Ella M
Anstey, Nicholas M
Currie, Bart J
Piera, Kim A
Baird, Robert
Sarovich, Derek S
Davis, Joshua S
author_sort Meumann, Ella M
collection PubMed
description Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3–56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.
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spelling pubmed-66023822019-07-05 Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia Meumann, Ella M Anstey, Nicholas M Currie, Bart J Piera, Kim A Baird, Robert Sarovich, Derek S Davis, Joshua S Open Forum Infect Dis Brief Report Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3–56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse. Oxford University Press 2019-06-01 /pmc/articles/PMC6602382/ /pubmed/31281860 http://dx.doi.org/10.1093/ofid/ofz263 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Meumann, Ella M
Anstey, Nicholas M
Currie, Bart J
Piera, Kim A
Baird, Robert
Sarovich, Derek S
Davis, Joshua S
Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title_full Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title_fullStr Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title_full_unstemmed Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title_short Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia
title_sort whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic acinetobacter baumannii pneumonia
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602382/
https://www.ncbi.nlm.nih.gov/pubmed/31281860
http://dx.doi.org/10.1093/ofid/ofz263
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