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GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server has been a valuable and highly cited resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. Here, we present GEPIA2, an updated and enhanced version to pro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602440/ https://www.ncbi.nlm.nih.gov/pubmed/31114875 http://dx.doi.org/10.1093/nar/gkz430 |
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author | Tang, Zefang Kang, Boxi Li, Chenwei Chen, Tianxiang Zhang, Zemin |
author_facet | Tang, Zefang Kang, Boxi Li, Chenwei Chen, Tianxiang Zhang, Zemin |
author_sort | Tang, Zefang |
collection | PubMed |
description | Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server has been a valuable and highly cited resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. Here, we present GEPIA2, an updated and enhanced version to provide insights with higher resolution and more functionalities. Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes. In addition, GEPIA2 has adopted new analysis techniques of gene signature quantification inspired by single-cell sequencing studies, and provides customized analysis where users can upload their own RNA-seq data and compare them with TCGA and GTEx samples. We also offer an API for batch process and easy retrieval of the analysis results. The updated web server is publicly accessible at http://gepia2.cancer-pku.cn/. |
format | Online Article Text |
id | pubmed-6602440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66024402019-07-05 GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis Tang, Zefang Kang, Boxi Li, Chenwei Chen, Tianxiang Zhang, Zemin Nucleic Acids Res Web Server Issue Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server has been a valuable and highly cited resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. Here, we present GEPIA2, an updated and enhanced version to provide insights with higher resolution and more functionalities. Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes. In addition, GEPIA2 has adopted new analysis techniques of gene signature quantification inspired by single-cell sequencing studies, and provides customized analysis where users can upload their own RNA-seq data and compare them with TCGA and GTEx samples. We also offer an API for batch process and easy retrieval of the analysis results. The updated web server is publicly accessible at http://gepia2.cancer-pku.cn/. Oxford University Press 2019-07-02 2019-05-22 /pmc/articles/PMC6602440/ /pubmed/31114875 http://dx.doi.org/10.1093/nar/gkz430 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Web Server Issue Tang, Zefang Kang, Boxi Li, Chenwei Chen, Tianxiang Zhang, Zemin GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title | GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title_full | GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title_fullStr | GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title_full_unstemmed | GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title_short | GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis |
title_sort | gepia2: an enhanced web server for large-scale expression profiling and interactive analysis |
topic | Web Server Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602440/ https://www.ncbi.nlm.nih.gov/pubmed/31114875 http://dx.doi.org/10.1093/nar/gkz430 |
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