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Yvis: antibody high-density alignment visualization and analysis platform with an integrated database

As antibodies are a very important tool for diagnosis, therapy, and experimental biology, a large number of antibody structures and sequences have become available in recent years. Therefore, tools that allow the analysis, comparison, and visualization of this large amount of antibody data are cruci...

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Detalles Bibliográficos
Autores principales: Carvalho, Milene B, Molina, Franck, Felicori, Liza F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602444/
https://www.ncbi.nlm.nih.gov/pubmed/31106372
http://dx.doi.org/10.1093/nar/gkz387
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author Carvalho, Milene B
Molina, Franck
Felicori, Liza F
author_facet Carvalho, Milene B
Molina, Franck
Felicori, Liza F
author_sort Carvalho, Milene B
collection PubMed
description As antibodies are a very important tool for diagnosis, therapy, and experimental biology, a large number of antibody structures and sequences have become available in recent years. Therefore, tools that allow the analysis, comparison, and visualization of this large amount of antibody data are crucially needed. We developed the antibody high-density alignment visualization and analysis (Yvis) platform to provide an innovative, robust and high-density data visualization of antibody sequence alignments, called Collier de Diamants. The Yvis platform also provides an integrated structural database, which is updated weekly, and many different search and filter options. This platform can help to formulate hypotheses concerning the key residues in antibody structures or interactions to improve the understanding of antibody properties. The Yvis platform is available at http://bioinfo.icb.ufmg.br/yvis/.
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spelling pubmed-66024442019-07-05 Yvis: antibody high-density alignment visualization and analysis platform with an integrated database Carvalho, Milene B Molina, Franck Felicori, Liza F Nucleic Acids Res Web Server Issue As antibodies are a very important tool for diagnosis, therapy, and experimental biology, a large number of antibody structures and sequences have become available in recent years. Therefore, tools that allow the analysis, comparison, and visualization of this large amount of antibody data are crucially needed. We developed the antibody high-density alignment visualization and analysis (Yvis) platform to provide an innovative, robust and high-density data visualization of antibody sequence alignments, called Collier de Diamants. The Yvis platform also provides an integrated structural database, which is updated weekly, and many different search and filter options. This platform can help to formulate hypotheses concerning the key residues in antibody structures or interactions to improve the understanding of antibody properties. The Yvis platform is available at http://bioinfo.icb.ufmg.br/yvis/. Oxford University Press 2019-07-02 2019-05-20 /pmc/articles/PMC6602444/ /pubmed/31106372 http://dx.doi.org/10.1093/nar/gkz387 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Web Server Issue
Carvalho, Milene B
Molina, Franck
Felicori, Liza F
Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title_full Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title_fullStr Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title_full_unstemmed Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title_short Yvis: antibody high-density alignment visualization and analysis platform with an integrated database
title_sort yvis: antibody high-density alignment visualization and analysis platform with an integrated database
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602444/
https://www.ncbi.nlm.nih.gov/pubmed/31106372
http://dx.doi.org/10.1093/nar/gkz387
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