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MEXPRESS update 2019

The recent growth in the number of publicly available cancer omics databases has been accompanied by the development of various tools that allow researchers to visually explore these data. In 2015, we built MEXPRESS, an online tool for the integration and visualization of gene expression, DNA methyl...

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Autores principales: Koch, Alexander, Jeschke, Jana, Van Criekinge, Wim, van Engeland, Manon, De Meyer, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602516/
https://www.ncbi.nlm.nih.gov/pubmed/31114869
http://dx.doi.org/10.1093/nar/gkz445
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author Koch, Alexander
Jeschke, Jana
Van Criekinge, Wim
van Engeland, Manon
De Meyer, Tim
author_facet Koch, Alexander
Jeschke, Jana
Van Criekinge, Wim
van Engeland, Manon
De Meyer, Tim
author_sort Koch, Alexander
collection PubMed
description The recent growth in the number of publicly available cancer omics databases has been accompanied by the development of various tools that allow researchers to visually explore these data. In 2015, we built MEXPRESS, an online tool for the integration and visualization of gene expression, DNA methylation and clinical data from The Cancer Genome Atlas (TCGA), a large collection of publicly available multi-omics cancer data. MEXPRESS addresses the need for an easy-to-use, interactive application that allows researchers to identify dysregulated genes and their clinical relevance in cancer. Furthermore, while other tools typically do not support integrated visualization of expression and DNA methylation data in combination with the precise genomic location of the methylation, MEXPRESS is unique in how it depicts these diverse data types together. Motivated by the large number of users MEXPRESS has managed to attract over the past 3 years and the recent migration of all TCGA data to a new data portal, we developed a new version of MEXPRESS (https://mexpress.be). It contains the latest TCGA data, additional types of omics and clinical data and extra functionality, allowing users to explore mechanisms of gene dysregulation beyond expression and DNA methylation.
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spelling pubmed-66025162019-07-05 MEXPRESS update 2019 Koch, Alexander Jeschke, Jana Van Criekinge, Wim van Engeland, Manon De Meyer, Tim Nucleic Acids Res Web Server Issue The recent growth in the number of publicly available cancer omics databases has been accompanied by the development of various tools that allow researchers to visually explore these data. In 2015, we built MEXPRESS, an online tool for the integration and visualization of gene expression, DNA methylation and clinical data from The Cancer Genome Atlas (TCGA), a large collection of publicly available multi-omics cancer data. MEXPRESS addresses the need for an easy-to-use, interactive application that allows researchers to identify dysregulated genes and their clinical relevance in cancer. Furthermore, while other tools typically do not support integrated visualization of expression and DNA methylation data in combination with the precise genomic location of the methylation, MEXPRESS is unique in how it depicts these diverse data types together. Motivated by the large number of users MEXPRESS has managed to attract over the past 3 years and the recent migration of all TCGA data to a new data portal, we developed a new version of MEXPRESS (https://mexpress.be). It contains the latest TCGA data, additional types of omics and clinical data and extra functionality, allowing users to explore mechanisms of gene dysregulation beyond expression and DNA methylation. Oxford University Press 2019-07-02 2019-05-22 /pmc/articles/PMC6602516/ /pubmed/31114869 http://dx.doi.org/10.1093/nar/gkz445 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Web Server Issue
Koch, Alexander
Jeschke, Jana
Van Criekinge, Wim
van Engeland, Manon
De Meyer, Tim
MEXPRESS update 2019
title MEXPRESS update 2019
title_full MEXPRESS update 2019
title_fullStr MEXPRESS update 2019
title_full_unstemmed MEXPRESS update 2019
title_short MEXPRESS update 2019
title_sort mexpress update 2019
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602516/
https://www.ncbi.nlm.nih.gov/pubmed/31114869
http://dx.doi.org/10.1093/nar/gkz445
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