Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can confer adaptive protection against oxidative and proteotoxic stress in cells. In this stud...

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Detalles Bibliográficos
Autores principales: Tang, Zehan, Hu, Bo, Zang, Fazhi, Wang, Jianxi, Zhang, Xingda, Chen, Huajiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602960/
https://www.ncbi.nlm.nih.gov/pubmed/31263165
http://dx.doi.org/10.1038/s41419-019-1701-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602960/
https://www.ncbi.nlm.nih.gov/pubmed/31263165
http://dx.doi.org/10.1038/s41419-019-1701-3

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