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Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing antibodies (bnAbs) but not for third variable regi...

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Detalles Bibliográficos
Autores principales:	Han, Qifeng, Jones, Julia A., Nicely, Nathan I., Reed, Rachel K., Shen, Xiaoying, Mansouri, Katayoun, Louder, Mark, Trama, Ashley M., Alam, S. Munir, Edwards, Robert J., Bonsignori, Mattia, Tomaras, Georgia D., Korber, Bette, Montefiori, David C., Mascola, John R., Seaman, Michael S., Haynes, Barton F., Saunders, Kevin O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602974/ https://www.ncbi.nlm.nih.gov/pubmed/31263112 http://dx.doi.org/10.1038/s41467-019-10899-2

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