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Structure and function of the Orc1 BAH-nucleosome complex

The Origin Recognition Complex (ORC) is essential for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes. Here we present the structure of the yeast Orc1 BAH domain bound to the nucleosome core particle. Our data reveal that Orc1, unlike its close homolog...

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Detalles Bibliográficos
Autores principales:	De Ioannes, Pablo, Leon, Victor A., Kuang, Zheng, Wang, Miao, Boeke, Jef D., Hochwagen, Andreas, Armache, Karim-Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602975/ https://www.ncbi.nlm.nih.gov/pubmed/31263106 http://dx.doi.org/10.1038/s41467-019-10609-y

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