Cargando…

The impact of Yohimbine-induced arousal on facets of behavioural impulsivity

RATIONALE: State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES: To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α(2)-adrenergic receptor antagonist, which increases physiological arousal via noradrenali...

Descripción completa

Detalles Bibliográficos
Autores principales: Herman, Aleksandra M., Critchley, Hugo D., Duka, Theodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602985/
https://www.ncbi.nlm.nih.gov/pubmed/30635680
http://dx.doi.org/10.1007/s00213-018-5160-9
_version_ 1783431428252368896
author Herman, Aleksandra M.
Critchley, Hugo D.
Duka, Theodora
author_facet Herman, Aleksandra M.
Critchley, Hugo D.
Duka, Theodora
author_sort Herman, Aleksandra M.
collection PubMed
description RATIONALE: State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES: To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α(2)-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performance on established laboratory-based impulsivity measures in healthy volunteers. METHODS: Forty-three participants received a single dose of either yohimbine hydrochloride or placebo before completing a battery of impulsivity measures. Blood pressure and heart rate were monitored throughout the study. RESULTS: Participants in the yohimbine group showed higher blood pressure and better response inhibition in the Stop Signal Task, relative to the placebo group. Additionally, individual changes in blood pressure were associated with performance on Delay Discounting and Information Sampling tasks: raised blood pressure following drug ingestion was associated with more far-sighted decisions in the Delay Discounting Task (lower temporal impulsivity) yet reduced information gathering in the Information Sampling Task (increased reflection impulsivity). CONCLUSIONS: These results support the notion that impulsive behaviour is dependent upon state physiological arousal; however, distinct facets of impulsivity are differentially affected by physiological changes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-018-5160-9) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6602985
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-66029852019-07-18 The impact of Yohimbine-induced arousal on facets of behavioural impulsivity Herman, Aleksandra M. Critchley, Hugo D. Duka, Theodora Psychopharmacology (Berl) Original Investigation RATIONALE: State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES: To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α(2)-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performance on established laboratory-based impulsivity measures in healthy volunteers. METHODS: Forty-three participants received a single dose of either yohimbine hydrochloride or placebo before completing a battery of impulsivity measures. Blood pressure and heart rate were monitored throughout the study. RESULTS: Participants in the yohimbine group showed higher blood pressure and better response inhibition in the Stop Signal Task, relative to the placebo group. Additionally, individual changes in blood pressure were associated with performance on Delay Discounting and Information Sampling tasks: raised blood pressure following drug ingestion was associated with more far-sighted decisions in the Delay Discounting Task (lower temporal impulsivity) yet reduced information gathering in the Information Sampling Task (increased reflection impulsivity). CONCLUSIONS: These results support the notion that impulsive behaviour is dependent upon state physiological arousal; however, distinct facets of impulsivity are differentially affected by physiological changes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00213-018-5160-9) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-01-11 2019 /pmc/articles/PMC6602985/ /pubmed/30635680 http://dx.doi.org/10.1007/s00213-018-5160-9 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Investigation
Herman, Aleksandra M.
Critchley, Hugo D.
Duka, Theodora
The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title_full The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title_fullStr The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title_full_unstemmed The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title_short The impact of Yohimbine-induced arousal on facets of behavioural impulsivity
title_sort impact of yohimbine-induced arousal on facets of behavioural impulsivity
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602985/
https://www.ncbi.nlm.nih.gov/pubmed/30635680
http://dx.doi.org/10.1007/s00213-018-5160-9
work_keys_str_mv AT hermanaleksandram theimpactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity
AT critchleyhugod theimpactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity
AT dukatheodora theimpactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity
AT hermanaleksandram impactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity
AT critchleyhugod impactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity
AT dukatheodora impactofyohimbineinducedarousalonfacetsofbehaviouralimpulsivity