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Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes

Accumulation of iron has been associated with the pathobiology of various disorders of the central nervous system. Our previous work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in multiple brain regions and that this was paralleled by i...

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Detalles Bibliográficos
Autores principales:	Chen, Zheng, Jiang, Ruiwei, Chen, Mengxia, Zheng, Jiashuo, Chen, Min, Braidy, Nady, Liu, Shunli, Liu, Guohao, Maimaitiming, Zaitunamu, Shen, Tianqi, Dunaief, Joshua L., Vulpe, Christopher D., Anderson, Gregory J., Chen, Huijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603037/ https://www.ncbi.nlm.nih.gov/pubmed/31263155 http://dx.doi.org/10.1038/s41598-019-46019-9

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