An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH2 in this setting is unclear due to the context-de...

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Detalles Bibliográficos
Autores principales: Smith, Harvey W., Hirukawa, Alison, Sanguin-Gendreau, Virginie, Nandi, Ipshita, Dufour, Catherine R., Zuo, Dongmei, Tandoc, Kristofferson, Leibovitch, Matthew, Singh, Salendra, Rennhack, Jonathan P., Swiatnicki, Matthew, Lavoie, Cynthia, Papavasiliou, Vasilios, Temps, Carolin, Carragher, Neil O., Unciti-Broceta, Asier, Savage, Paul, Basik, Mark, van Hoef, Vincent, Larsson, Ola, Cooper, Caroline L., Vargas Calderon, Ana Cristina, Beith, Jane, Millar, Ewan, Selinger, Christina, Giguère, Vincent, Park, Morag, Harris, Lyndsay N., Varadan, Vinay, Andrechek, Eran R., O’Toole, Sandra A., Topisirovic, Ivan, Muller, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603039/
https://www.ncbi.nlm.nih.gov/pubmed/31263101
http://dx.doi.org/10.1038/s41467-019-10681-4

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