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A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276

BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecule...

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Autores principales: Yu, Xiaobo, Wei, Bajin, Su, Rong, Yao, Jia, Feng, Xiaowen, Jiang, Guoping, Xie, Haiyang, Wu, Jian, Xu, Xiao, Zhang, Min, Zheng, Shusen, Zhou, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603397/
https://www.ncbi.nlm.nih.gov/pubmed/31044564
http://dx.doi.org/10.1002/mgg3.689
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author Yu, Xiaobo
Wei, Bajin
Su, Rong
Yao, Jia
Feng, Xiaowen
Jiang, Guoping
Xie, Haiyang
Wu, Jian
Xu, Xiao
Zhang, Min
Zheng, Shusen
Zhou, Lin
author_facet Yu, Xiaobo
Wei, Bajin
Su, Rong
Yao, Jia
Feng, Xiaowen
Jiang, Guoping
Xie, Haiyang
Wu, Jian
Xu, Xiao
Zhang, Min
Zheng, Shusen
Zhou, Lin
author_sort Yu, Xiaobo
collection PubMed
description BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecules, CD276, and its ligand, TREML2, promotes T cell‐mediated immune response, as well as acute or chronic allograft rejection. Our research aimed at correlating genetic polymorphisms of CD276/TREML2 with acute rejection, and evaluating its prognostic value of acute rejection after liver transplantation. METHODS: The study enrolled a total of 388 recipients. Among them, acute allograft rejection was observed in 54 cases. We performed single nucleotide polymorphism genotyping of CD276, including rs11072431, rs11574495, rs12593558, rs12594627, rs2127015, rs3816661 and rs7176654, and TREML2, including rs4714431, rs6915083, rs7754593, and rs9394767 from preoperative peripheral blood genome DNA. RESULTS: We found rs2127015 of CD276, rs6915083 and rs7754593 of TREML2, and HBV infection as well were associated with acute rejection. And, rs2127015 influences CD276 expression. Moreover, we established a risk assessment model, composited by statistically proved risk factors. CONCLUSION: By integrating both clinical and genetic variables, liver transplant recipients can be categorized into different risk groups, and might benefit from individualized therapies.
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spelling pubmed-66033972019-07-31 A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276 Yu, Xiaobo Wei, Bajin Su, Rong Yao, Jia Feng, Xiaowen Jiang, Guoping Xie, Haiyang Wu, Jian Xu, Xiao Zhang, Min Zheng, Shusen Zhou, Lin Mol Genet Genomic Med Original Articles BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecules, CD276, and its ligand, TREML2, promotes T cell‐mediated immune response, as well as acute or chronic allograft rejection. Our research aimed at correlating genetic polymorphisms of CD276/TREML2 with acute rejection, and evaluating its prognostic value of acute rejection after liver transplantation. METHODS: The study enrolled a total of 388 recipients. Among them, acute allograft rejection was observed in 54 cases. We performed single nucleotide polymorphism genotyping of CD276, including rs11072431, rs11574495, rs12593558, rs12594627, rs2127015, rs3816661 and rs7176654, and TREML2, including rs4714431, rs6915083, rs7754593, and rs9394767 from preoperative peripheral blood genome DNA. RESULTS: We found rs2127015 of CD276, rs6915083 and rs7754593 of TREML2, and HBV infection as well were associated with acute rejection. And, rs2127015 influences CD276 expression. Moreover, we established a risk assessment model, composited by statistically proved risk factors. CONCLUSION: By integrating both clinical and genetic variables, liver transplant recipients can be categorized into different risk groups, and might benefit from individualized therapies. John Wiley and Sons Inc. 2019-05-01 /pmc/articles/PMC6603397/ /pubmed/31044564 http://dx.doi.org/10.1002/mgg3.689 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Yu, Xiaobo
Wei, Bajin
Su, Rong
Yao, Jia
Feng, Xiaowen
Jiang, Guoping
Xie, Haiyang
Wu, Jian
Xu, Xiao
Zhang, Min
Zheng, Shusen
Zhou, Lin
A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title_full A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title_fullStr A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title_full_unstemmed A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title_short A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
title_sort risk assessment model of acute liver allograft rejection by genetic polymorphism of cd276
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603397/
https://www.ncbi.nlm.nih.gov/pubmed/31044564
http://dx.doi.org/10.1002/mgg3.689
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