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A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecule...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603397/ https://www.ncbi.nlm.nih.gov/pubmed/31044564 http://dx.doi.org/10.1002/mgg3.689 |
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author | Yu, Xiaobo Wei, Bajin Su, Rong Yao, Jia Feng, Xiaowen Jiang, Guoping Xie, Haiyang Wu, Jian Xu, Xiao Zhang, Min Zheng, Shusen Zhou, Lin |
author_facet | Yu, Xiaobo Wei, Bajin Su, Rong Yao, Jia Feng, Xiaowen Jiang, Guoping Xie, Haiyang Wu, Jian Xu, Xiao Zhang, Min Zheng, Shusen Zhou, Lin |
author_sort | Yu, Xiaobo |
collection | PubMed |
description | BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecules, CD276, and its ligand, TREML2, promotes T cell‐mediated immune response, as well as acute or chronic allograft rejection. Our research aimed at correlating genetic polymorphisms of CD276/TREML2 with acute rejection, and evaluating its prognostic value of acute rejection after liver transplantation. METHODS: The study enrolled a total of 388 recipients. Among them, acute allograft rejection was observed in 54 cases. We performed single nucleotide polymorphism genotyping of CD276, including rs11072431, rs11574495, rs12593558, rs12594627, rs2127015, rs3816661 and rs7176654, and TREML2, including rs4714431, rs6915083, rs7754593, and rs9394767 from preoperative peripheral blood genome DNA. RESULTS: We found rs2127015 of CD276, rs6915083 and rs7754593 of TREML2, and HBV infection as well were associated with acute rejection. And, rs2127015 influences CD276 expression. Moreover, we established a risk assessment model, composited by statistically proved risk factors. CONCLUSION: By integrating both clinical and genetic variables, liver transplant recipients can be categorized into different risk groups, and might benefit from individualized therapies. |
format | Online Article Text |
id | pubmed-6603397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66033972019-07-31 A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276 Yu, Xiaobo Wei, Bajin Su, Rong Yao, Jia Feng, Xiaowen Jiang, Guoping Xie, Haiyang Wu, Jian Xu, Xiao Zhang, Min Zheng, Shusen Zhou, Lin Mol Genet Genomic Med Original Articles BACKGROUND: Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection. The interaction between costimulatory molecules, CD276, and its ligand, TREML2, promotes T cell‐mediated immune response, as well as acute or chronic allograft rejection. Our research aimed at correlating genetic polymorphisms of CD276/TREML2 with acute rejection, and evaluating its prognostic value of acute rejection after liver transplantation. METHODS: The study enrolled a total of 388 recipients. Among them, acute allograft rejection was observed in 54 cases. We performed single nucleotide polymorphism genotyping of CD276, including rs11072431, rs11574495, rs12593558, rs12594627, rs2127015, rs3816661 and rs7176654, and TREML2, including rs4714431, rs6915083, rs7754593, and rs9394767 from preoperative peripheral blood genome DNA. RESULTS: We found rs2127015 of CD276, rs6915083 and rs7754593 of TREML2, and HBV infection as well were associated with acute rejection. And, rs2127015 influences CD276 expression. Moreover, we established a risk assessment model, composited by statistically proved risk factors. CONCLUSION: By integrating both clinical and genetic variables, liver transplant recipients can be categorized into different risk groups, and might benefit from individualized therapies. John Wiley and Sons Inc. 2019-05-01 /pmc/articles/PMC6603397/ /pubmed/31044564 http://dx.doi.org/10.1002/mgg3.689 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Yu, Xiaobo Wei, Bajin Su, Rong Yao, Jia Feng, Xiaowen Jiang, Guoping Xie, Haiyang Wu, Jian Xu, Xiao Zhang, Min Zheng, Shusen Zhou, Lin A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276 |
title | A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
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title_full | A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
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title_fullStr | A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
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title_full_unstemmed | A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
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title_short | A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276
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title_sort | risk assessment model of acute liver allograft rejection by genetic polymorphism of cd276 |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603397/ https://www.ncbi.nlm.nih.gov/pubmed/31044564 http://dx.doi.org/10.1002/mgg3.689 |
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