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Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns

The aim of this study was to assess the influence of active tobacco smoke exposure in utero on the concentration of hepcidin and selected iron markers in umbilical cord blood and to evaluate the relationships between these parameters. Newborns of smoking mothers had significantly lower concentration...

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Autores principales: Chełchowska, Magdalena, Maciejewski, Tomasz M., Mazur, Joanna, Gajewska, Joanna, Zasimovich, Anastasiya, Ołtarzewski, Mariusz, Ambroszkiewicz, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603951/
https://www.ncbi.nlm.nih.gov/pubmed/31195607
http://dx.doi.org/10.3390/ijerph16111996
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author Chełchowska, Magdalena
Maciejewski, Tomasz M.
Mazur, Joanna
Gajewska, Joanna
Zasimovich, Anastasiya
Ołtarzewski, Mariusz
Ambroszkiewicz, Jadwiga
author_facet Chełchowska, Magdalena
Maciejewski, Tomasz M.
Mazur, Joanna
Gajewska, Joanna
Zasimovich, Anastasiya
Ołtarzewski, Mariusz
Ambroszkiewicz, Jadwiga
author_sort Chełchowska, Magdalena
collection PubMed
description The aim of this study was to assess the influence of active tobacco smoke exposure in utero on the concentration of hepcidin and selected iron markers in umbilical cord blood and to evaluate the relationships between these parameters. Newborns of smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron, and ferritin (p = 0.043; p = 0.042, respectively), but higher levels of erythropoietin (EPO, p < 0.001) and soluble transferrin receptor (sTfR, p = 0.011) compared with newborns of non-smoking women. Negative correlations between cotinine and the number of cigarettes smoked per day with hepcidin serum level (r = −0.33, p = 0.033, r = −0.32, p = 0.041, respectively) and EPO (r = 0.47, p = 0.002; r = 0.46, p = 0.003, respectively) were found. Univariate analysis defined for the whole group of children revealed significant associations between the concentration of hepcidin and other iron status parameters. In the models estimated separately for smokers and non-smokers, we found relations between the level of hepcidin and erythropoietin (B = −0.23, p = 0.004; B = −0.46, p = 0.01, respectively). In the multivariate regression model, a negative association between hepcidin and EPO concentrations in the whole group of newborns (β = −0.53; p = 0.001) and in the group of smokers (β = −0.57; p = 0.011) was confirmed. The present study shows significant relations between smoking during pregnancy and hepcidin levels in children born at term. Decreased cord serum concentrations of hepcidin associated with high erythropoietin levels suggest induced fetal erythropoiesis, probably due to the hypoxic effects imposed by maternal smoking.
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spelling pubmed-66039512019-07-19 Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns Chełchowska, Magdalena Maciejewski, Tomasz M. Mazur, Joanna Gajewska, Joanna Zasimovich, Anastasiya Ołtarzewski, Mariusz Ambroszkiewicz, Jadwiga Int J Environ Res Public Health Article The aim of this study was to assess the influence of active tobacco smoke exposure in utero on the concentration of hepcidin and selected iron markers in umbilical cord blood and to evaluate the relationships between these parameters. Newborns of smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron, and ferritin (p = 0.043; p = 0.042, respectively), but higher levels of erythropoietin (EPO, p < 0.001) and soluble transferrin receptor (sTfR, p = 0.011) compared with newborns of non-smoking women. Negative correlations between cotinine and the number of cigarettes smoked per day with hepcidin serum level (r = −0.33, p = 0.033, r = −0.32, p = 0.041, respectively) and EPO (r = 0.47, p = 0.002; r = 0.46, p = 0.003, respectively) were found. Univariate analysis defined for the whole group of children revealed significant associations between the concentration of hepcidin and other iron status parameters. In the models estimated separately for smokers and non-smokers, we found relations between the level of hepcidin and erythropoietin (B = −0.23, p = 0.004; B = −0.46, p = 0.01, respectively). In the multivariate regression model, a negative association between hepcidin and EPO concentrations in the whole group of newborns (β = −0.53; p = 0.001) and in the group of smokers (β = −0.57; p = 0.011) was confirmed. The present study shows significant relations between smoking during pregnancy and hepcidin levels in children born at term. Decreased cord serum concentrations of hepcidin associated with high erythropoietin levels suggest induced fetal erythropoiesis, probably due to the hypoxic effects imposed by maternal smoking. MDPI 2019-06-05 2019-06 /pmc/articles/PMC6603951/ /pubmed/31195607 http://dx.doi.org/10.3390/ijerph16111996 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chełchowska, Magdalena
Maciejewski, Tomasz M.
Mazur, Joanna
Gajewska, Joanna
Zasimovich, Anastasiya
Ołtarzewski, Mariusz
Ambroszkiewicz, Jadwiga
Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title_full Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title_fullStr Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title_full_unstemmed Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title_short Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns
title_sort active tobacco smoke exposure in utero and concentrations of hepcidin and selected iron parameters in newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603951/
https://www.ncbi.nlm.nih.gov/pubmed/31195607
http://dx.doi.org/10.3390/ijerph16111996
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