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A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

BACKGROUND: Triple negative breast cancers (TNBCs) have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The malignant and invasive feature of TNBCs is correlated with its high cancer stem cell population. Recent results from us and others have unveiled an oncogenic ro...

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Detalles Bibliográficos
Autores principales:	Zhou, Zhuan, Feng, Zhiwei, Hu, Dong, Yang, Peng, Gur, Mert, Bahar, Ivet, Cristofanilli, Massimo, Gradishar, William J., Xie, Xiang-qun, Wan, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604046/ https://www.ncbi.nlm.nih.gov/pubmed/31101597 http://dx.doi.org/10.1016/j.ebiom.2019.05.011

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