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Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans
BACKGROUND: Genetic diversity is known to confer survival advantage in many species across the tree of life. Here, we hypothesize that such pattern applies to humans as well and could be a result of higher fitness in individuals with higher genomic heterozygosity. RESULTS: We use healthy aging as a...
Autores principales: | Xu, Ke, Kosoy, Roman, Shameer, Khader, Kumar, Sudhir, Liu, Li, Readhead, Ben, Belbin, Gillian M., Lee, Hao-Chih, Chen, Rong, Dudley, Joel T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604157/ https://www.ncbi.nlm.nih.gov/pubmed/31266448 http://dx.doi.org/10.1186/s12863-019-0758-4 |
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