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The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study

BACKGROUND: We aimed to examine the association of dietary acid load and prediabetes in a case–control study. METHODS: This study recruited 297 subjects including 147 prediabetic subjects and 150 controls referred to diabetes screening center in Shahreza, Iran. Participants were frequency-matched by...

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Autores principales: Abshirini, Maryam, Bagheri, Fariba, Mahaki, Behzad, Siassi, Fereydoun, Koohdani, Fariba, Safabakhsh, Maryam, Sotoudeh, Gity
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604202/
https://www.ncbi.nlm.nih.gov/pubmed/31303897
http://dx.doi.org/10.1186/s13098-019-0447-5
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author Abshirini, Maryam
Bagheri, Fariba
Mahaki, Behzad
Siassi, Fereydoun
Koohdani, Fariba
Safabakhsh, Maryam
Sotoudeh, Gity
author_facet Abshirini, Maryam
Bagheri, Fariba
Mahaki, Behzad
Siassi, Fereydoun
Koohdani, Fariba
Safabakhsh, Maryam
Sotoudeh, Gity
author_sort Abshirini, Maryam
collection PubMed
description BACKGROUND: We aimed to examine the association of dietary acid load and prediabetes in a case–control study. METHODS: This study recruited 297 subjects including 147 prediabetic subjects and 150 controls referred to diabetes screening center in Shahreza, Iran. Participants were frequency-matched by sex and age. Blood pressure, anthropometric measures and blood glucose levels were measured. Dietary intake was assessed using a validated 168-items food frequency questionnaire (FFQ). The dietary acid load scores including the potential renal acid load (PRAL) and net endogenous acid production (NEAP) were calculated based on nutrients intake. NEAP and PRAL scores were categorized by quartiles based on the distribution of controls. Logistic regression models were used to estimate multivariable odds ratio (OR) of prediabetes across the energy-adjusted and sex-specific quartiles of NEAP and PRAL scores. RESULTS: Participants of control group in the higher quartiles of NEAP and PRAL tended to have higher body weight compared to the lower quartiles (P-trend < 0.04). After adjustment for multiple confounding variables, participants in the highest quartiles of NEAP and PRAL had increased OR for prediabetes (OR = 14.48 95% CI 5.64–37.19), and (OR = 25.61 95% CI 9.63–68.08) (P-trend < 0.001), respectively. CONCLUSION: Our data indicated subjects with prediabetes had diets with more acid-forming potential than control group. Our findings suggest that higher dietary acid load was associated with increased prediabetes morbidity. Interventional studies are warranted to elucidate the role of acidogenic diets in the development of prediabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0447-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-66042022019-07-12 The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study Abshirini, Maryam Bagheri, Fariba Mahaki, Behzad Siassi, Fereydoun Koohdani, Fariba Safabakhsh, Maryam Sotoudeh, Gity Diabetol Metab Syndr Research BACKGROUND: We aimed to examine the association of dietary acid load and prediabetes in a case–control study. METHODS: This study recruited 297 subjects including 147 prediabetic subjects and 150 controls referred to diabetes screening center in Shahreza, Iran. Participants were frequency-matched by sex and age. Blood pressure, anthropometric measures and blood glucose levels were measured. Dietary intake was assessed using a validated 168-items food frequency questionnaire (FFQ). The dietary acid load scores including the potential renal acid load (PRAL) and net endogenous acid production (NEAP) were calculated based on nutrients intake. NEAP and PRAL scores were categorized by quartiles based on the distribution of controls. Logistic regression models were used to estimate multivariable odds ratio (OR) of prediabetes across the energy-adjusted and sex-specific quartiles of NEAP and PRAL scores. RESULTS: Participants of control group in the higher quartiles of NEAP and PRAL tended to have higher body weight compared to the lower quartiles (P-trend < 0.04). After adjustment for multiple confounding variables, participants in the highest quartiles of NEAP and PRAL had increased OR for prediabetes (OR = 14.48 95% CI 5.64–37.19), and (OR = 25.61 95% CI 9.63–68.08) (P-trend < 0.001), respectively. CONCLUSION: Our data indicated subjects with prediabetes had diets with more acid-forming potential than control group. Our findings suggest that higher dietary acid load was associated with increased prediabetes morbidity. Interventional studies are warranted to elucidate the role of acidogenic diets in the development of prediabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13098-019-0447-5) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-01 /pmc/articles/PMC6604202/ /pubmed/31303897 http://dx.doi.org/10.1186/s13098-019-0447-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Abshirini, Maryam
Bagheri, Fariba
Mahaki, Behzad
Siassi, Fereydoun
Koohdani, Fariba
Safabakhsh, Maryam
Sotoudeh, Gity
The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title_full The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title_fullStr The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title_full_unstemmed The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title_short The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
title_sort dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604202/
https://www.ncbi.nlm.nih.gov/pubmed/31303897
http://dx.doi.org/10.1186/s13098-019-0447-5
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