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CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity
CRISPR-based nucleic acid detection methods are reported to facilitate rapid and sensitive DNA detection. However, precise DNA detection at the single-base resolution and its wide applications including high-fidelity SNP genotyping remain to be explored. Here we develop a Cas12b-mediated DNA detecti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604390/ https://www.ncbi.nlm.nih.gov/pubmed/31262344 http://dx.doi.org/10.1186/s13059-019-1742-z |