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Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion
BACKGROUND: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations perfor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604441/ https://www.ncbi.nlm.nih.gov/pubmed/31262311 http://dx.doi.org/10.1186/s13019-019-0948-1 |
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author | Ghaidan, Haider Fakhro, Mohammed Andreasson, Jesper Pierre, Leif Ingemansson, Richard Lindstedt, Sandra |
author_facet | Ghaidan, Haider Fakhro, Mohammed Andreasson, Jesper Pierre, Leif Ingemansson, Richard Lindstedt, Sandra |
author_sort | Ghaidan, Haider |
collection | PubMed |
description | BACKGROUND: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. METHOD: Between 2006 and 2007, 21 patients (6 EVLP, 15 conventional) underwent double lung transplantation (LTx) with follow-up on May 2017 at Lund University Hospital, Sweden. Pulmonary function was measured at 3/6/12 months, and annually thereafter for a period of 10 years in addition to survival and freedom from chronic lung allograft dysfunction (CLAD) being analyzed. RESULTS: Regarding Forced Expiratory Volume in 1 s (FEV1) and 6MWT at 3, 6, and 12 months and annually thereafter, no difference in median FEV1 nor 6MWT was found for EVLP-LTx vs. conventional-LTx (p > 0.05). No difference was shown in post-operative survival between EVLP-LTx vs. conventional LTx for patients with an overall survival up to 10-years (p > 0.05). The same pattern was shown in sub analyses for patients with a limited survival up to 1 and 5 years (p > 0.05). CONCLUSION: No superiority was found in conventional-LTx over EVLP-LTx, neither in long-term survival nor pulmonary function. No difference in CLAD-free survival was seen between the two groups. We believe that EVLP is a safe and effective method to use in LTx, greatly increasing the donor pool by improving marginal lungs and providing an objective assessment of the viability of marginal donor lungs. |
format | Online Article Text |
id | pubmed-6604441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66044412019-07-12 Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion Ghaidan, Haider Fakhro, Mohammed Andreasson, Jesper Pierre, Leif Ingemansson, Richard Lindstedt, Sandra J Cardiothorac Surg Research Article BACKGROUND: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. METHOD: Between 2006 and 2007, 21 patients (6 EVLP, 15 conventional) underwent double lung transplantation (LTx) with follow-up on May 2017 at Lund University Hospital, Sweden. Pulmonary function was measured at 3/6/12 months, and annually thereafter for a period of 10 years in addition to survival and freedom from chronic lung allograft dysfunction (CLAD) being analyzed. RESULTS: Regarding Forced Expiratory Volume in 1 s (FEV1) and 6MWT at 3, 6, and 12 months and annually thereafter, no difference in median FEV1 nor 6MWT was found for EVLP-LTx vs. conventional-LTx (p > 0.05). No difference was shown in post-operative survival between EVLP-LTx vs. conventional LTx for patients with an overall survival up to 10-years (p > 0.05). The same pattern was shown in sub analyses for patients with a limited survival up to 1 and 5 years (p > 0.05). CONCLUSION: No superiority was found in conventional-LTx over EVLP-LTx, neither in long-term survival nor pulmonary function. No difference in CLAD-free survival was seen between the two groups. We believe that EVLP is a safe and effective method to use in LTx, greatly increasing the donor pool by improving marginal lungs and providing an objective assessment of the viability of marginal donor lungs. BioMed Central 2019-07-01 /pmc/articles/PMC6604441/ /pubmed/31262311 http://dx.doi.org/10.1186/s13019-019-0948-1 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Ghaidan, Haider Fakhro, Mohammed Andreasson, Jesper Pierre, Leif Ingemansson, Richard Lindstedt, Sandra Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title | Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title_full | Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title_fullStr | Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title_full_unstemmed | Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title_short | Ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
title_sort | ten year follow-up of lung transplantations using initially rejected donor lungs after reconditioning using ex vivo lung perfusion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604441/ https://www.ncbi.nlm.nih.gov/pubmed/31262311 http://dx.doi.org/10.1186/s13019-019-0948-1 |
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