Animal models of necrotizing enterocolitis: review of the literature and state of the art

Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal surgical emergency in preterm neonates. Over the last five decades, a variety of experimental models have been developed to study the pathophysiology of this disease and to test the effectiveness of novel therapeutic strat...

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Autores principales: Sulistyo, Adrienne, Rahman, Abidur, Biouss, George, Antounians, Lina, Zani, Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604570/
https://www.ncbi.nlm.nih.gov/pubmed/31579771
http://dx.doi.org/10.1515/iss-2017-0050
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author Sulistyo, Adrienne
Rahman, Abidur
Biouss, George
Antounians, Lina
Zani, Augusto
author_facet Sulistyo, Adrienne
Rahman, Abidur
Biouss, George
Antounians, Lina
Zani, Augusto
author_sort Sulistyo, Adrienne
collection PubMed
description Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal surgical emergency in preterm neonates. Over the last five decades, a variety of experimental models have been developed to study the pathophysiology of this disease and to test the effectiveness of novel therapeutic strategies. Experimental NEC is mainly modeled in neonatal rats, mice and piglets. In this review, we focus on these experimental models and discuss the major advantages and disadvantages of each. We also briefly discuss other models that are not as widely used but have contributed to our current knowledge of NEC.
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spelling pubmed-66045702019-10-02 Animal models of necrotizing enterocolitis: review of the literature and state of the art Sulistyo, Adrienne Rahman, Abidur Biouss, George Antounians, Lina Zani, Augusto Innov Surg Sci Reviews Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal surgical emergency in preterm neonates. Over the last five decades, a variety of experimental models have been developed to study the pathophysiology of this disease and to test the effectiveness of novel therapeutic strategies. Experimental NEC is mainly modeled in neonatal rats, mice and piglets. In this review, we focus on these experimental models and discuss the major advantages and disadvantages of each. We also briefly discuss other models that are not as widely used but have contributed to our current knowledge of NEC. De Gruyter 2018-03-10 /pmc/articles/PMC6604570/ /pubmed/31579771 http://dx.doi.org/10.1515/iss-2017-0050 Text en ©2018 Sulistyo A., et al., published by De Gruyter, Berlin/Boston http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Reviews
Sulistyo, Adrienne
Rahman, Abidur
Biouss, George
Antounians, Lina
Zani, Augusto
Animal models of necrotizing enterocolitis: review of the literature and state of the art
title Animal models of necrotizing enterocolitis: review of the literature and state of the art
title_full Animal models of necrotizing enterocolitis: review of the literature and state of the art
title_fullStr Animal models of necrotizing enterocolitis: review of the literature and state of the art
title_full_unstemmed Animal models of necrotizing enterocolitis: review of the literature and state of the art
title_short Animal models of necrotizing enterocolitis: review of the literature and state of the art
title_sort animal models of necrotizing enterocolitis: review of the literature and state of the art
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604570/
https://www.ncbi.nlm.nih.gov/pubmed/31579771
http://dx.doi.org/10.1515/iss-2017-0050
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