Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-...

Descripción completa

Detalles Bibliográficos
Autores principales: Murlykina, Maryna V, Kolomiets, Oleksandr V, Kornet, Maryna M, Sakhno, Yana I, Desenko, Sergey M, Dyakonenko, Victoriya V, Shishkina, Svetlana V, Brazhko, Oleksandr A, Musatov, Vladimir I, Tsygankov, Alexander V, Van der Eycken, Erik V, Chebanov, Valentyn A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604699/
https://www.ncbi.nlm.nih.gov/pubmed/31293676
http://dx.doi.org/10.3762/bjoc.15.126
Descripción
Sumario:Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.

Ejemplares similares