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Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604699/ https://www.ncbi.nlm.nih.gov/pubmed/31293676 http://dx.doi.org/10.3762/bjoc.15.126 |
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author | Murlykina, Maryna V Kolomiets, Oleksandr V Kornet, Maryna M Sakhno, Yana I Desenko, Sergey M Dyakonenko, Victoriya V Shishkina, Svetlana V Brazhko, Oleksandr A Musatov, Vladimir I Tsygankov, Alexander V Van der Eycken, Erik V Chebanov, Valentyn A |
author_facet | Murlykina, Maryna V Kolomiets, Oleksandr V Kornet, Maryna M Sakhno, Yana I Desenko, Sergey M Dyakonenko, Victoriya V Shishkina, Svetlana V Brazhko, Oleksandr A Musatov, Vladimir I Tsygankov, Alexander V Van der Eycken, Erik V Chebanov, Valentyn A |
author_sort | Murlykina, Maryna V |
collection | PubMed |
description | Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity. |
format | Online Article Text |
id | pubmed-6604699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-66046992019-07-10 Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction Murlykina, Maryna V Kolomiets, Oleksandr V Kornet, Maryna M Sakhno, Yana I Desenko, Sergey M Dyakonenko, Victoriya V Shishkina, Svetlana V Brazhko, Oleksandr A Musatov, Vladimir I Tsygankov, Alexander V Van der Eycken, Erik V Chebanov, Valentyn A Beilstein J Org Chem Full Research Paper Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity. Beilstein-Institut 2019-06-12 /pmc/articles/PMC6604699/ /pubmed/31293676 http://dx.doi.org/10.3762/bjoc.15.126 Text en Copyright © 2019, Murlykina et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Murlykina, Maryna V Kolomiets, Oleksandr V Kornet, Maryna M Sakhno, Yana I Desenko, Sergey M Dyakonenko, Victoriya V Shishkina, Svetlana V Brazhko, Oleksandr A Musatov, Vladimir I Tsygankov, Alexander V Van der Eycken, Erik V Chebanov, Valentyn A Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title | Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title_full | Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title_fullStr | Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title_full_unstemmed | Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title_short | Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction |
title_sort | doebner-type pyrazolopyridine carboxylic acids in an ugi four-component reaction |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604699/ https://www.ncbi.nlm.nih.gov/pubmed/31293676 http://dx.doi.org/10.3762/bjoc.15.126 |
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