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Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif
We report the metabolism of the recently introduced α,α-difluoroethyl thioether motif to explore further its potential as a substituent for bioactives discovery chemistry. Incubation of two aryl–SCF(2)CH(3) ethers with the model yeast organism Cunninghamella elegans, indicates that the sulfur of the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604701/ https://www.ncbi.nlm.nih.gov/pubmed/31293694 http://dx.doi.org/10.3762/bjoc.15.144 |