Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance

NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA(SEP)) and Staphylococcus haemolyticus (norA(SHAE)) were identified and sequenced. The nucleotide identity o...

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Detalles Bibliográficos
Autores principales: Marco, Ligozzi, Liliana, Galia, Anna, Bertoncelli, Annarita, Mazzariol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604952/
https://www.ncbi.nlm.nih.gov/pubmed/31294197
http://dx.doi.org/10.3934/microbiol.2017.4.908
Descripción
Sumario:NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA(SEP)) and Staphylococcus haemolyticus (norA(SHAE)) were identified and sequenced. The nucleotide identity of norA(SEP) and norA(SHAE) with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA(SEP) increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA(SEP) EZ cat norA(SEP) plasmid.

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