Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance

NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA(SEP)) and Staphylococcus haemolyticus (norA(SHAE)) were identified and sequenced. The nucleotide identity o...

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Autores principales: Marco, Ligozzi, Liliana, Galia, Anna, Bertoncelli, Annarita, Mazzariol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604952/
https://www.ncbi.nlm.nih.gov/pubmed/31294197
http://dx.doi.org/10.3934/microbiol.2017.4.908
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author Marco, Ligozzi
Liliana, Galia
Anna, Bertoncelli
Annarita, Mazzariol
author_facet Marco, Ligozzi
Liliana, Galia
Anna, Bertoncelli
Annarita, Mazzariol
author_sort Marco, Ligozzi
collection PubMed
description NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA(SEP)) and Staphylococcus haemolyticus (norA(SHAE)) were identified and sequenced. The nucleotide identity of norA(SEP) and norA(SHAE) with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA(SEP) increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA(SEP) EZ cat norA(SEP) plasmid.
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spelling pubmed-66049522019-07-10 Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance Marco, Ligozzi Liliana, Galia Anna, Bertoncelli Annarita, Mazzariol AIMS Microbiol Research Article NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA(SEP)) and Staphylococcus haemolyticus (norA(SHAE)) were identified and sequenced. The nucleotide identity of norA(SEP) and norA(SHAE) with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA(SEP) increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA(SEP) EZ cat norA(SEP) plasmid. AIMS Press 2017-11-14 /pmc/articles/PMC6604952/ /pubmed/31294197 http://dx.doi.org/10.3934/microbiol.2017.4.908 Text en © 2017 Mazzariol Annarita, et al., licensee AIMS Press This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
spellingShingle Research Article
Marco, Ligozzi
Liliana, Galia
Anna, Bertoncelli
Annarita, Mazzariol
Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title_full Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title_fullStr Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title_full_unstemmed Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title_short Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance
title_sort intrinsic role of coagulase negative staphylococci nora-like efflux system in fluoroquinolones resistance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604952/
https://www.ncbi.nlm.nih.gov/pubmed/31294197
http://dx.doi.org/10.3934/microbiol.2017.4.908
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