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Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

The past two decades have witnessed major breakthroughs in developing compounds that target the chloride channel CFTR for the treatment of patients with cystic fibrosis. However, further improvement in affinity and efficacy for these CFTR modulators will require insights into the molecular interacti...

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Detalles Bibliográficos
Autores principales:	Yeh, Han-I, Qiu, Liming, Sohma, Yoshiro, Conrath, Katja, Zou, Xiaoqin, Hwang, Tzyh-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605684/ https://www.ncbi.nlm.nih.gov/pubmed/31164398 http://dx.doi.org/10.1085/jgp.201912360

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