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Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis

Streptococcus pyogenes (Group A streptococcus; GAS) is a human pathogen causing diseases from uncomplicated tonsillitis to life-threatening invasive infections. GAS secretes EndoS, an endoglycosidase that specifically cleaves the conserved N-glycan on IgG antibodies. In vitro, removal of this glycan...

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Detalles Bibliográficos
Autores principales:	Naegeli, Andreas, Bratanis, Eleni, Karlsson, Christofer, Shannon, Oonagh, Kalluru, Raja, Linder, Adam, Malmström, Johan, Collin, Mattias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605743/ https://www.ncbi.nlm.nih.gov/pubmed/31092533 http://dx.doi.org/10.1084/jem.20190293

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