Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)(SWE)/presenilin 1 (PS1)(ΔE9) transgenic model of Aβ amyloidosis. We now show that in an independent, aggr...

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Detalles Bibliográficos
Autores principales: Dodiya, Hemraj B., Kuntz, Thomas, Shaik, Shabana M., Baufeld, Caroline, Leibowitz, Jeffrey, Zhang, Xulun, Gottel, Neil, Zhang, Xiaoqiong, Butovsky, Oleg, Gilbert, Jack A., Sisodia, Sangram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605759/
https://www.ncbi.nlm.nih.gov/pubmed/31097468
http://dx.doi.org/10.1084/jem.20182386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605759/
https://www.ncbi.nlm.nih.gov/pubmed/31097468
http://dx.doi.org/10.1084/jem.20182386

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