Rab46 integrates Ca(2+) and histamine signaling to regulate selective cargo release from Weibel-Palade bodies

Endothelial cells selectively release cargo stored in Weibel-Palade bodies (WPBs) to regulate vascular function, but the underlying mechanisms are poorly understood. Here we show that histamine evokes the release of the proinflammatory ligand, P-selectin, while diverting WPBs carrying non-inflammato...

Descripción completa

Detalles Bibliográficos
Autores principales: Miteva, Katarina T., Pedicini, Lucia, Wilson, Lesley A., Jayasinghe, Izzy, Slip, Raphael G., Marszalek, Katarzyna, Gaunt, Hannah J., Bartoli, Fiona, Deivasigamani, Shruthi, Sobradillo, Diego, Beech, David J., McKeown, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605797/
https://www.ncbi.nlm.nih.gov/pubmed/31092558
http://dx.doi.org/10.1083/jcb.201810118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605797/
https://www.ncbi.nlm.nih.gov/pubmed/31092558
http://dx.doi.org/10.1083/jcb.201810118

Ejemplares similares