Phosphorylation of G3BP1-S149 does not influence stress granule assembly

Tourrière et al. (2003. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation st...

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Detalles Bibliográficos
Autores principales: Panas, Marc D., Kedersha, Nancy, Schulte, Tim, Branca, Rui M., Ivanov, Pavel, Anderson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605800/
https://www.ncbi.nlm.nih.gov/pubmed/31171631
http://dx.doi.org/10.1083/jcb.201801214
Descripción
Sumario:Tourrière et al. (2003. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation status does not change upon stress.

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