Phosphorylation of G3BP1-S149 does not influence stress granule assembly

Tourrière et al. (2003. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation st...

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Autores principales: Panas, Marc D., Kedersha, Nancy, Schulte, Tim, Branca, Rui M., Ivanov, Pavel, Anderson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605800/
https://www.ncbi.nlm.nih.gov/pubmed/31171631
http://dx.doi.org/10.1083/jcb.201801214
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author Panas, Marc D.
Kedersha, Nancy
Schulte, Tim
Branca, Rui M.
Ivanov, Pavel
Anderson, Paul
author_facet Panas, Marc D.
Kedersha, Nancy
Schulte, Tim
Branca, Rui M.
Ivanov, Pavel
Anderson, Paul
author_sort Panas, Marc D.
collection PubMed
description Tourrière et al. (2003. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation status does not change upon stress.
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spelling pubmed-66058002020-01-01 Phosphorylation of G3BP1-S149 does not influence stress granule assembly Panas, Marc D. Kedersha, Nancy Schulte, Tim Branca, Rui M. Ivanov, Pavel Anderson, Paul J Cell Biol Letters Tourrière et al. (2003. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation status does not change upon stress. Rockefeller University Press 2019-07-01 2019-06-06 /pmc/articles/PMC6605800/ /pubmed/31171631 http://dx.doi.org/10.1083/jcb.201801214 Text en © 2019 Panas et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Letters
Panas, Marc D.
Kedersha, Nancy
Schulte, Tim
Branca, Rui M.
Ivanov, Pavel
Anderson, Paul
Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title_full Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title_fullStr Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title_full_unstemmed Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title_short Phosphorylation of G3BP1-S149 does not influence stress granule assembly
title_sort phosphorylation of g3bp1-s149 does not influence stress granule assembly
topic Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605800/
https://www.ncbi.nlm.nih.gov/pubmed/31171631
http://dx.doi.org/10.1083/jcb.201801214
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