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Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China

Introduction: Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good...

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Autores principales: Wang, Xiaoli, An, Zhijie, Huo, Da, Jia, Lei, Li, Jie, Yang, Yang, Liang, Zhichao, Wang, Quanyi, Wang, Huaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605830/
https://www.ncbi.nlm.nih.gov/pubmed/30779680
http://dx.doi.org/10.1080/21645515.2019.1581539
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author Wang, Xiaoli
An, Zhijie
Huo, Da
Jia, Lei
Li, Jie
Yang, Yang
Liang, Zhichao
Wang, Quanyi
Wang, Huaqing
author_facet Wang, Xiaoli
An, Zhijie
Huo, Da
Jia, Lei
Li, Jie
Yang, Yang
Liang, Zhichao
Wang, Quanyi
Wang, Huaqing
author_sort Wang, Xiaoli
collection PubMed
description Introduction: Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good efficacy for preventing EV-A71-associated disease in clinical trials. However, real-world performance of EV-A71 vaccine has not been evaluated. Methods: We used a test-negative design case-control study to estimate vaccine effectiveness (VE) against medically attended EV-A71-associated HFMD. Subjects were children 5 years of age and under who had been in health facilities participating in the HFMD case and virologic surveillance platforms in Beijing. Enterovirus infections were laboratory confirmed, and EV-A71 vaccination status was extracted from electronic immunization records. Children testing positive for EV-A71 were cases; controls were children testing negative for EV-A71 infection. Logistic regression was used to estimate VE. We assessed sensitivity of VE estimates to control group inclusion criteria by repeating the regression analyses with two alternative control groups. Results: A total of 2,184 HFMD patients aged 5 years and under were enrolled in the study; 24 were severe, and 2,160 were mild. For severe cases, two-dose VE estimate was 100% (95% CI: −68.1%, 100%). For mild cases, 1-dose and 2-dose adjusted VE estimates were 69.8% and 83.7%, respectively. Two-dose VE estimates varied by less than 4 percentage points regardless of control group definition. Conclusions: Our findings suggested the vaccines performed well in the real world for children 5 years of age and under in Beijing, China.
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spelling pubmed-66058302019-07-09 Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China Wang, Xiaoli An, Zhijie Huo, Da Jia, Lei Li, Jie Yang, Yang Liang, Zhichao Wang, Quanyi Wang, Huaqing Hum Vaccin Immunother Research Paper Introduction: Enterovirus A71(EV-A71)-associated hand, foot, and mouth disease (HFMD) has been reported worldwide, and poses a particularly heavy burden on patients, families, and society in China. Three Chinese companies have licensed inactivated EV-A71 vaccines, all of which have demonstrated good efficacy for preventing EV-A71-associated disease in clinical trials. However, real-world performance of EV-A71 vaccine has not been evaluated. Methods: We used a test-negative design case-control study to estimate vaccine effectiveness (VE) against medically attended EV-A71-associated HFMD. Subjects were children 5 years of age and under who had been in health facilities participating in the HFMD case and virologic surveillance platforms in Beijing. Enterovirus infections were laboratory confirmed, and EV-A71 vaccination status was extracted from electronic immunization records. Children testing positive for EV-A71 were cases; controls were children testing negative for EV-A71 infection. Logistic regression was used to estimate VE. We assessed sensitivity of VE estimates to control group inclusion criteria by repeating the regression analyses with two alternative control groups. Results: A total of 2,184 HFMD patients aged 5 years and under were enrolled in the study; 24 were severe, and 2,160 were mild. For severe cases, two-dose VE estimate was 100% (95% CI: −68.1%, 100%). For mild cases, 1-dose and 2-dose adjusted VE estimates were 69.8% and 83.7%, respectively. Two-dose VE estimates varied by less than 4 percentage points regardless of control group definition. Conclusions: Our findings suggested the vaccines performed well in the real world for children 5 years of age and under in Beijing, China. Taylor & Francis 2019-03-20 /pmc/articles/PMC6605830/ /pubmed/30779680 http://dx.doi.org/10.1080/21645515.2019.1581539 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Research Paper
Wang, Xiaoli
An, Zhijie
Huo, Da
Jia, Lei
Li, Jie
Yang, Yang
Liang, Zhichao
Wang, Quanyi
Wang, Huaqing
Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title_full Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title_fullStr Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title_full_unstemmed Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title_short Enterovirus A71 vaccine effectiveness in preventing enterovirus A71 infection among medically-attended hand, foot, and mouth disease cases, Beijing, China
title_sort enterovirus a71 vaccine effectiveness in preventing enterovirus a71 infection among medically-attended hand, foot, and mouth disease cases, beijing, china
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605830/
https://www.ncbi.nlm.nih.gov/pubmed/30779680
http://dx.doi.org/10.1080/21645515.2019.1581539
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