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Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age
Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adoles...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606021/ https://www.ncbi.nlm.nih.gov/pubmed/31262402 http://dx.doi.org/10.7554/eLife.44056 |
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author | Kühn, Simone Mascharek, Anna Banaschewski, Tobias Bodke, Arun Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny A Heinz, Andreas Ittermann, Bernd Martinot, Jean-Luc Nees, Frauke Papadopoulos Orfanos, Dimitri Paus, Tomas Poustka, Luise Millenet, Sabina Fröhner, Juliane H Smolka, Michael N Walter, Henrik Whelan, Robert Schumann, Gunter Lindenberger, Ulman Gallinat, Jürgen |
author_facet | Kühn, Simone Mascharek, Anna Banaschewski, Tobias Bodke, Arun Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny A Heinz, Andreas Ittermann, Bernd Martinot, Jean-Luc Nees, Frauke Papadopoulos Orfanos, Dimitri Paus, Tomas Poustka, Luise Millenet, Sabina Fröhner, Juliane H Smolka, Michael N Walter, Henrik Whelan, Robert Schumann, Gunter Lindenberger, Ulman Gallinat, Jürgen |
author_sort | Kühn, Simone |
collection | PubMed |
description | Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging. |
format | Online Article Text |
id | pubmed-6606021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-66060212019-07-03 Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age Kühn, Simone Mascharek, Anna Banaschewski, Tobias Bodke, Arun Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny A Heinz, Andreas Ittermann, Bernd Martinot, Jean-Luc Nees, Frauke Papadopoulos Orfanos, Dimitri Paus, Tomas Poustka, Luise Millenet, Sabina Fröhner, Juliane H Smolka, Michael N Walter, Henrik Whelan, Robert Schumann, Gunter Lindenberger, Ulman Gallinat, Jürgen eLife Neuroscience Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging. eLife Sciences Publications, Ltd 2019-07-02 /pmc/articles/PMC6606021/ /pubmed/31262402 http://dx.doi.org/10.7554/eLife.44056 Text en © 2019, Kühn et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Kühn, Simone Mascharek, Anna Banaschewski, Tobias Bodke, Arun Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny A Heinz, Andreas Ittermann, Bernd Martinot, Jean-Luc Nees, Frauke Papadopoulos Orfanos, Dimitri Paus, Tomas Poustka, Luise Millenet, Sabina Fröhner, Juliane H Smolka, Michael N Walter, Henrik Whelan, Robert Schumann, Gunter Lindenberger, Ulman Gallinat, Jürgen Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title | Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title_full | Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title_fullStr | Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title_full_unstemmed | Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title_short | Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
title_sort | predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606021/ https://www.ncbi.nlm.nih.gov/pubmed/31262402 http://dx.doi.org/10.7554/eLife.44056 |
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