Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

BACKGROUND: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bon...

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Detalles Bibliográficos
Autores principales: Marino, Silvia, de Ridder, Daniëlle, Bishop, Ryan T., Renema, Nathalie, Ponzetti, Marco, Sophocleous, Antonia, Capulli, Mattia, Aljeffery, Abdullah, Carrasco, Giovana, Gens, Marianela Dalghi, Khogeer, Asim, Ralston, Stuart H., Gertsch, Jürg, Lamoureux, Francois, Heymann, Dominique, Rucci, Nadia, Idris, Aymen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606522/
https://www.ncbi.nlm.nih.gov/pubmed/31151929
http://dx.doi.org/10.1016/j.ebiom.2019.05.048

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