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Molecular tuning of farnesoid X receptor partial agonism

The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several metabolic pathologies but pharmacological administration of full FXR agonists has been plagued by mechanism-based side effects. We have devel...

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Detalles Bibliográficos
Autores principales:	Merk, Daniel, Sreeramulu, Sridhar, Kudlinzki, Denis, Saxena, Krishna, Linhard, Verena, Gande, Santosh L., Hiller, Fabian, Lamers, Christina, Nilsson, Ewa, Aagaard, Anna, Wissler, Lisa, Dekker, Niek, Bamberg, Krister, Schubert-Zsilavecz, Manfred, Schwalbe, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606567/ https://www.ncbi.nlm.nih.gov/pubmed/31266946 http://dx.doi.org/10.1038/s41467-019-10853-2

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