Cargando…
Chemical logic of MraY inhibition by antibacterial nucleoside natural products
Novel antibacterial agents are needed to address the emergence of global antibiotic resistance. MraY is a promising candidate for antibiotic development because it is the target of five classes of naturally occurring nucleoside inhibitors with potent antibacterial activity. Although these natural pr...
Autores principales: | Mashalidis, Ellene H., Kaeser, Benjamin, Terasawa, Yuma, Katsuyama, Akira, Kwon, Do-Yeon, Lee, Kiyoun, Hong, Jiyong, Ichikawa, Satoshi, Lee, Seok-Yong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606608/ https://www.ncbi.nlm.nih.gov/pubmed/31266949 http://dx.doi.org/10.1038/s41467-019-10957-9 |
Ejemplares similares
-
Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY
por: Nakaya, Takeshi, et al.
Publicado: (2022) -
Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors
por: Chen, Kuo-Ting, et al.
Publicado: (2016) -
New MraY(AA) Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole
por: Wan, Hongwei, et al.
Publicado: (2022) -
Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters
por: Johnson, Zachary Lee, et al.
Publicado: (2014) -
GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation
por: Yoo, Jiho, et al.
Publicado: (2018)