Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mi...

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Detalles Bibliográficos
Autores principales: Dash, Prasanta K., Kaminski, Rafal, Bella, Ramona, Su, Hang, Mathews, Saumi, Ahooyi, Taha M., Chen, Chen, Mancuso, Pietro, Sariyer, Rahsan, Ferrante, Pasquale, Donadoni, Martina, Robinson, Jake A., Sillman, Brady, Lin, Zhiyi, Hilaire, James R., Banoub, Mary, Elango, Monalisha, Gautam, Nagsen, Mosley, R. Lee, Poluektova, Larisa Y., McMillan, JoEllyn, Bade, Aditya N., Gorantla, Santhi, Sariyer, Ilker K., Burdo, Tricia H., Young, Won-Bin, Amini, Shohreh, Gordon, Jennifer, Jacobson, Jeffrey M., Edagwa, Benson, Khalili, Kamel, Gendelman, Howard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606613/
https://www.ncbi.nlm.nih.gov/pubmed/31266936
http://dx.doi.org/10.1038/s41467-019-10366-y

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