Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome

Cathepsin S (CTSS) is highly increased in Sjögren’s syndrome (SS) patients tears and in tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mice, a murine model of SS. To explore CTSS’s utility as a therapeutic target for mitigating ocular manifestations of SS in sites where CTSS is incr...

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Detalles Bibliográficos
Autores principales: Klinngam, Wannita, Janga, Srikanth R., Lee, Changrim, Ju, Yaping, Yarber, Frances, Shah, Mihir, Guo, Hao, Wang, Dandan, MacKay, J. Andrew, Edman, Maria C., Hamm-Alvarez, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606642/
https://www.ncbi.nlm.nih.gov/pubmed/31267034
http://dx.doi.org/10.1038/s41598-019-45966-7

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