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Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment cau...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606643/ https://www.ncbi.nlm.nih.gov/pubmed/31286064 http://dx.doi.org/10.1038/s42003-019-0495-2 |