Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons

Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment cau...

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Detalles Bibliográficos
Autores principales: Descalzi, Giannina, Gao, Virginia, Steinman, Michael Q., Suzuki, Akinobu, Alberini, Cristina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606643/
https://www.ncbi.nlm.nih.gov/pubmed/31286064
http://dx.doi.org/10.1038/s42003-019-0495-2

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