Cargando…
Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis
miR-146a has been implicated in the regulation of the immune response as well as in inflammatory process of atherosclerosis. In the present study, we have investigated the expression of miR-146a and its targets, TLR4 a IRAK1, in aortic valve stenosis. A total of 58 patients with aortic stenosis (non...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606704/ https://www.ncbi.nlm.nih.gov/pubmed/31294031 http://dx.doi.org/10.3389/fcvm.2019.00086 |
_version_ | 1783431949540392960 |
---|---|
author | Petrkova, Jana Borucka, Jana Kalab, Martin Klevcova, Petra Michalek, Jaroslav Taborsky, Milos Petrek, Martin |
author_facet | Petrkova, Jana Borucka, Jana Kalab, Martin Klevcova, Petra Michalek, Jaroslav Taborsky, Milos Petrek, Martin |
author_sort | Petrkova, Jana |
collection | PubMed |
description | miR-146a has been implicated in the regulation of the immune response as well as in inflammatory process of atherosclerosis. In the present study, we have investigated the expression of miR-146a and its targets, TLR4 a IRAK1, in aortic valve stenosis. A total of 58 patients with aortic stenosis (non- and atherosclerotic; tissue obtained during standard aortic valve replacement) were enrolled. The relative expression of mir-146a was higher in valvular tissue from patients with atherosclerosis compared to those without atherosclerosis (p = 0.01). Number of the IRAK1 and TLR4 transcripts did not differ between the investigated groups. There was a trend toward elevation of miR-146a expression in context of inflammatory infiltrate observed in the valvular tissue from patients with atherosclerosis (p = 0.06). In conclusion, in line with the acknowledged role of miR-146a in atherosclerotic inflammation, our data suggest it may be extended to the specific location of aortic valves in aortic stenosis. |
format | Online Article Text |
id | pubmed-6606704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66067042019-07-10 Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis Petrkova, Jana Borucka, Jana Kalab, Martin Klevcova, Petra Michalek, Jaroslav Taborsky, Milos Petrek, Martin Front Cardiovasc Med Cardiovascular Medicine miR-146a has been implicated in the regulation of the immune response as well as in inflammatory process of atherosclerosis. In the present study, we have investigated the expression of miR-146a and its targets, TLR4 a IRAK1, in aortic valve stenosis. A total of 58 patients with aortic stenosis (non- and atherosclerotic; tissue obtained during standard aortic valve replacement) were enrolled. The relative expression of mir-146a was higher in valvular tissue from patients with atherosclerosis compared to those without atherosclerosis (p = 0.01). Number of the IRAK1 and TLR4 transcripts did not differ between the investigated groups. There was a trend toward elevation of miR-146a expression in context of inflammatory infiltrate observed in the valvular tissue from patients with atherosclerosis (p = 0.06). In conclusion, in line with the acknowledged role of miR-146a in atherosclerotic inflammation, our data suggest it may be extended to the specific location of aortic valves in aortic stenosis. Frontiers Media S.A. 2019-06-26 /pmc/articles/PMC6606704/ /pubmed/31294031 http://dx.doi.org/10.3389/fcvm.2019.00086 Text en Copyright © 2019 Petrkova, Borucka, Kalab, Klevcova, Michalek, Taborsky and Petrek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Petrkova, Jana Borucka, Jana Kalab, Martin Klevcova, Petra Michalek, Jaroslav Taborsky, Milos Petrek, Martin Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title | Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title_full | Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title_fullStr | Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title_full_unstemmed | Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title_short | Increased Expression of miR-146a in Valvular Tissue From Patients With Aortic Valve Stenosis |
title_sort | increased expression of mir-146a in valvular tissue from patients with aortic valve stenosis |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606704/ https://www.ncbi.nlm.nih.gov/pubmed/31294031 http://dx.doi.org/10.3389/fcvm.2019.00086 |
work_keys_str_mv | AT petrkovajana increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT boruckajana increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT kalabmartin increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT klevcovapetra increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT michalekjaroslav increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT taborskymilos increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis AT petrekmartin increasedexpressionofmir146ainvalvulartissuefrompatientswithaorticvalvestenosis |