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Generation and Validation of miR-100 Hepatocyte-Specific Knock-Out Mice

Background: Inactivation of microRNA-100 (miR-100) is involved in hepatocellular carcinoma (HCC) and miR-100 behaves as a tumor suppressor. To understand miR-100 function in HCC genesis and development in vivo, we developed hepatocyte-specific miR-100 deficient mice. Methods: Mice homozygous for flo...

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Detalles Bibliográficos
Autores principales:	Yang, Dong, Tang, Sai, Yang, Yan, Yang, Fan, Jiang, Wengang, Liu, Yakun, Zhang, Fengyun, Fang, Haoshu, Wang, Siying, Zhang, Yuxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606737/ https://www.ncbi.nlm.nih.gov/pubmed/31293973 http://dx.doi.org/10.3389/fonc.2019.00535

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