Fas signaling-mediated T(H)9 cell differentiation favors bowel inflammation and antitumor functions

Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes T(H)9 cell differentiation by activating NF-κB via Ca(2+)-dependent PKC-β activation. In addition, PKC-β also phosphoryla...

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Detalles Bibliográficos
Autores principales: Shen, Yingying, Song, Zhengbo, Lu, Xinliang, Ma, Zeyu, Lu, Chaojie, Zhang, Bei, Chen, Yinghu, Duan, Meng, Apetoh, Lionel, Li, Xu, Guo, Jufeng, Miao, Ying, Zhang, Gensheng, Yang, Diya, Cai, Zhijian, Wang, Jianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606754/
https://www.ncbi.nlm.nih.gov/pubmed/31266950
http://dx.doi.org/10.1038/s41467-019-10889-4

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