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Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease
More than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606788/ https://www.ncbi.nlm.nih.gov/pubmed/31293558 http://dx.doi.org/10.3389/fmicb.2019.01435 |
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author | Calderón-Peláez, María-Angélica Velandia-Romero, Myriam L. Bastidas-Legarda, Leidy Y. Beltrán, Edgar O. Camacho-Ortega, Sigrid J. Castellanos, Jaime E. |
author_facet | Calderón-Peláez, María-Angélica Velandia-Romero, Myriam L. Bastidas-Legarda, Leidy Y. Beltrán, Edgar O. Camacho-Ortega, Sigrid J. Castellanos, Jaime E. |
author_sort | Calderón-Peláez, María-Angélica |
collection | PubMed |
description | More than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic neurotropic and neurovirulent features of flaviviruses like DENV. Using in vivo and in vitro models, researchers have demonstrated that DENV can affect the cells from the blood–brain barrier (BBB) in several ways, which could result in brain tissue damage, neuronal loss, glial activation, tissue inflammation and hemorrhages. The latter suggests that BBB may be compromised during infection; however, it is not clear whether the damage is due to the infection per se or to the local and/or systemic inflammatory response established or activated by the BBB cells. Similarly, the kinetics and cascade of events that trigger tissue damage, and the cells that initiate it, are unknown. This review presents evidence of the BBB cell infection with DENV and the response established toward it by these cells; it also describes the consequences of this response on the nervous tissue, compares these evidence with the one reported with neurotropic viruses of the Flaviviridae family, and shows the complexity and unpredictability of dengue and the neurological alterations induced by it. Clinical evidence and in vitro and in vivo models suggest that this virus uses the bloodstream to enter nerve tissue where it infects the different cells of the neurovascular unit. Each of the cell populations respond individually and collectively and control infection and inflammation, in other cases this response exacerbates the damage leaving irreversible sequelae or causing death. This information will allow us to understand more about the complex disease known as dengue, and its impact on a specialized and delicate tissue like is the nervous tissue. |
format | Online Article Text |
id | pubmed-6606788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66067882019-07-10 Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease Calderón-Peláez, María-Angélica Velandia-Romero, Myriam L. Bastidas-Legarda, Leidy Y. Beltrán, Edgar O. Camacho-Ortega, Sigrid J. Castellanos, Jaime E. Front Microbiol Microbiology More than 500 million people worldwide are infected each year by any of the four-dengue virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and some patients may develop neurological alterations during or after the infection, which could be explained by the cryptic neurotropic and neurovirulent features of flaviviruses like DENV. Using in vivo and in vitro models, researchers have demonstrated that DENV can affect the cells from the blood–brain barrier (BBB) in several ways, which could result in brain tissue damage, neuronal loss, glial activation, tissue inflammation and hemorrhages. The latter suggests that BBB may be compromised during infection; however, it is not clear whether the damage is due to the infection per se or to the local and/or systemic inflammatory response established or activated by the BBB cells. Similarly, the kinetics and cascade of events that trigger tissue damage, and the cells that initiate it, are unknown. This review presents evidence of the BBB cell infection with DENV and the response established toward it by these cells; it also describes the consequences of this response on the nervous tissue, compares these evidence with the one reported with neurotropic viruses of the Flaviviridae family, and shows the complexity and unpredictability of dengue and the neurological alterations induced by it. Clinical evidence and in vitro and in vivo models suggest that this virus uses the bloodstream to enter nerve tissue where it infects the different cells of the neurovascular unit. Each of the cell populations respond individually and collectively and control infection and inflammation, in other cases this response exacerbates the damage leaving irreversible sequelae or causing death. This information will allow us to understand more about the complex disease known as dengue, and its impact on a specialized and delicate tissue like is the nervous tissue. Frontiers Media S.A. 2019-06-26 /pmc/articles/PMC6606788/ /pubmed/31293558 http://dx.doi.org/10.3389/fmicb.2019.01435 Text en Copyright © 2019 Calderón-Peláez, Velandia-Romero, Bastidas-Legarda, Beltrán, Camacho-Ortega and Castellanos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Calderón-Peláez, María-Angélica Velandia-Romero, Myriam L. Bastidas-Legarda, Leidy Y. Beltrán, Edgar O. Camacho-Ortega, Sigrid J. Castellanos, Jaime E. Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title | Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title_full | Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title_fullStr | Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title_full_unstemmed | Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title_short | Dengue Virus Infection of Blood–Brain Barrier Cells: Consequences of Severe Disease |
title_sort | dengue virus infection of blood–brain barrier cells: consequences of severe disease |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606788/ https://www.ncbi.nlm.nih.gov/pubmed/31293558 http://dx.doi.org/10.3389/fmicb.2019.01435 |
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