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Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIV(smm/mac) Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

As a consequence of their independent evolutionary origins in apes and Old World monkeys, human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses of the SIV(smm/mac) lineage express phylogenetically and antigenically distinct envelope glycoproteins. Thus, HIV-1 Env-specific a...

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Detalles Bibliográficos
Autores principales: von Bredow, Benjamin, Andrabi, Raiees, Grunst, Michael, Grandea, Andres G., Le, Khoa, Song, Ge, Berndsen, Zachary T., Porter, Katelyn, Pallesen, Jesper, Ward, Andrew B., Burton, Dennis R., Evans, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606807/
https://www.ncbi.nlm.nih.gov/pubmed/31266872
http://dx.doi.org/10.1128/mBio.01255-19