Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors, amplifying viral mRNA expression. The Tat inhibitor didehydro-cortistatin A (dCA) promotes a state of persistent latency, refractory to viral...

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Detalles Bibliográficos
Autores principales: Mousseau, Guillaume, Aneja, Rachna, Clementz, Mark A., Mediouni, Sonia, Lima, Noemia S., Haregot, Alexander, Kessing, Cari F., Jablonski, Joseph A., Thenin-Houssier, Suzie, Nagarsheth, Nisha, Trautmann, Lydie, Valente, Susana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606815/
https://www.ncbi.nlm.nih.gov/pubmed/31266880
http://dx.doi.org/10.1128/mBio.01750-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606815/
https://www.ncbi.nlm.nih.gov/pubmed/31266880
http://dx.doi.org/10.1128/mBio.01750-18

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