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Integrating Ligand-Receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands

To discover DNA ligands against a predetermined receptor protein complex, we introduce a comprehensive version of ligand-guided selection (LIGS). LIGS is, itself, a variant of systematic evolution of ligands by exponential enrichment (SELEX). Herein, we have optimized LIGS to identify higher affinit...

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Detalles Bibliográficos
Autores principales:	Zumrut, Hasan E., Batool, Sana, Argyropoulos, Kimon V., Williams, Nicole, Azad, Roksana, Mallikaratchy, Prabodhika R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606840/ https://www.ncbi.nlm.nih.gov/pubmed/31255977 http://dx.doi.org/10.1016/j.omtn.2019.05.015

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