Cargando…

Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine monophosphate response element-binding protein (CREB)/brain-derived neurotrophic factor (BDN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Mal-Soon, Kim, Tae-Won, Park, Sang-Seo, Ko, Il-Gyu, Kim, Chang-Ju, Kim, Mia, Roh, Su Yeon, Kim, Kwang Taek, Kim, Khae Hawn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Continence Society 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606934/ https://www.ncbi.nlm.nih.gov/pubmed/31260611 http://dx.doi.org/10.5213/inj.1938103.052

Ejemplares similares

“RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
por: Cseh, Botond, et al.
Publicado: (2014)

Rhynchosia volubilis Promotes Cell Survival via cAMP-PKA/ERK-CREB Pathway
por: Ahn, Sang-Hyun, et al.
Publicado: (2022)

MeBib Suppressed Methamphetamine Self-Administration Response via Inhibition of BDNF/ERK/CREB Signal Pathway in the Hippocampus
por: Kim, Buyun, et al.
Publicado: (2020)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
por: Wu, Pui-Kei, et al.
Publicado: (2020)

Administration of Phytoceramide Enhances Memory and Upregulates the Expression of pCREB and BDNF in Hippocampus of Mice
por: Lee, Yeonju, et al.
Publicado: (2013)

Global view of the RAF-MEK-ERK module and its immediate downstream effectors
por: Santini, Cristina C., et al.
Publicado: (2019)

Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils
por: Lee, Su-Shin, et al.
Publicado: (2020)

Antidepressive Effects of Kamishoyosan through 5-HT1AReceptor and PKA-CREB-BDNF Signaling in the Hippocampus in Postmenopausal Depression-Model Mice
por: Shimizu, Shoko, et al.
Publicado: (2019)

PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine
por: Xue, Wenda, et al.
Publicado: (2016)

Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
por: Gonzalez-Hormazabal, Patricio, et al.
Publicado: (2018)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
por: Degirmenci, Ufuk, et al.
Publicado: (2020)

Mumefural Improves Recognition Memory and Alters ERK-CREB-BDNF Signaling in a Mouse Model of Chronic Cerebral Hypoperfusion
por: Kim, Min-Soo, et al.
Publicado: (2023)

Anti-depressant effects of oil from fructus gardeniae via PKA-CREB-BDNF signaling
por: Ruan, Jie, et al.
Publicado: (2019)

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation
por: Wang, Xiaojuan, et al.
Publicado: (2020)

PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling
por: Wu, Chengyuan, et al.
Publicado: (2023)

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin
por: Kim, Taejin, et al.
Publicado: (2022)

Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication
por: Jeon, Ji Hyun, et al.
Publicado: (2020)

Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling
por: Mazein, Alexander, et al.
Publicado: (2021)

Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth
por: Chilamakuri, Rameswari, et al.
Publicado: (2022)

cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress
por: Luo, Ying, et al.
Publicado: (2017)

α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways
por: Ru, Yusha, et al.
Publicado: (2015)

Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
por: Merighi, Stefania, et al.
Publicado: (2006)

Combination Therapies to Inhibit the RAF/MEK/ERK Pathway in Melanoma: We are not Done Yet
por: McArthur, Grant A.
Publicado: (2015)

The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC
por: Li, Lei, et al.
Publicado: (2016)

RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway
por: Xie, Guojin, et al.
Publicado: (2019)

Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation
por: Avery, Thomas Yul, et al.
Publicado: (2022)

Laser Acupuncture Exerts Neuroprotective Effects via Regulation of Creb, Bdnf, Bcl-2, and Bax Gene Expressions in the Hippocampus
por: Yun, Yeong-Chan, et al.
Publicado: (2017)

Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway
por: Zhao, Jili, et al.
Publicado: (2021)

Antidepressants modulate glycine action in rat hippocampus
por: Chang, Hyun-Kyung, et al.
Publicado: (2015)

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
por: Nickols, Nicholas G., et al.
Publicado: (2019)

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway
por: Gunawardhana, Niluka, et al.
Publicado: (2018)

Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway
por: Zheng, Jie, et al.
Publicado: (2014)

Molecular signaling in multiple myeloma: association of RAS/RAF mutations and MEK/ERK pathway activation
por: Xu, J, et al.
Publicado: (2017)

Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
por: Du, Wei, et al.
Publicado: (2021)

Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study
por: Kim, Jin Won, et al.
Publicado: (2019)

Atorvastatin inhibits insulin synthesis by inhibiting the Ras/Raf/ERK/CREB pathway in INS-1 cells
por: Sun, Hongxi, et al.
Publicado: (2016)

Effect of treadmill exercise and bone marrow stromal cell engraftment on activation of BDNF-ERK-CREB signaling pathway in the crushed sciatic nerve
por: Seo, Tae-Beom, et al.
Publicado: (2021)

Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex
por: Yan, Lijing, et al.
Publicado: (2020)

The PKA-CREB system encoded by the honeybee genome
por: Eisenhardt, D, et al.
Publicado: (2006)

Effects of Ketamine on Learning and Memory in the Hippocampus of Rats through ERK, CREB, and Arc
por: Shi, Mingxian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_eko3palboh5r5f8ktcmlu0524d