α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface

Amyloid fibril surfaces can convert soluble proteins into toxic oligomers and are attractive targets for intervention of protein aggregation diseases. Thus far, molecules identified with inhibitory activity are either large proteins or flat cyclic compounds lacking in specificity. The main design di...

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Detalles Bibliográficos
Autores principales: Jiang, Yixiang, Jiang, Xuehan, Shi, Xiaodong, Yang, Fadeng, Cao, Yang, Qin, Xuan, Hou, Zhanfeng, Xie, Mingsheng, Liu, Na, Fang, Qi, Yin, Feng, Han, Wei, Li, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606958/
https://www.ncbi.nlm.nih.gov/pubmed/31255986
http://dx.doi.org/10.1016/j.isci.2019.06.022

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