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Non-clinical pharmacokinetic behavior of ginsenosides
Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth o...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606970/ https://www.ncbi.nlm.nih.gov/pubmed/31308806 http://dx.doi.org/10.1016/j.jgr.2018.06.001 |
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author | Won, Hyo-Joong Kim, Hyun Il Park, Taejun Kim, Hyeongmin Jo, Kanghee Jeon, Hyojin Ha, Seo Jun Hyun, Jung Min Jeong, Aeri Kim, Jung Sik Park, Ye Jin Eo, Yun Ho Lee, Jaehwi |
author_facet | Won, Hyo-Joong Kim, Hyun Il Park, Taejun Kim, Hyeongmin Jo, Kanghee Jeon, Hyojin Ha, Seo Jun Hyun, Jung Min Jeong, Aeri Kim, Jung Sik Park, Ye Jin Eo, Yun Ho Lee, Jaehwi |
author_sort | Won, Hyo-Joong |
collection | PubMed |
description | Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth of literature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensive studies that investigate their pharmacokinetic behaviors. This is because ginseng contains the complicated mixture of herbal materials as well as thousands of constituents with complex chemical properties, and ginsenosides undergo multiple biotransformation processes after administration. This is a significant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety of compounds. Moreover, there have been many difficulties in the development of the optimal dosage regimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this review details the pharmacokinetic properties and profiles of ginsenosides determined in various animal models administered through different routes of administration. Such information is valuable for designing specialized delivery systems and determining optimal dosing strategies for ginsenosides. |
format | Online Article Text |
id | pubmed-6606970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66069702019-07-15 Non-clinical pharmacokinetic behavior of ginsenosides Won, Hyo-Joong Kim, Hyun Il Park, Taejun Kim, Hyeongmin Jo, Kanghee Jeon, Hyojin Ha, Seo Jun Hyun, Jung Min Jeong, Aeri Kim, Jung Sik Park, Ye Jin Eo, Yun Ho Lee, Jaehwi J Ginseng Res Short Review Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth of literature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensive studies that investigate their pharmacokinetic behaviors. This is because ginseng contains the complicated mixture of herbal materials as well as thousands of constituents with complex chemical properties, and ginsenosides undergo multiple biotransformation processes after administration. This is a significant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety of compounds. Moreover, there have been many difficulties in the development of the optimal dosage regimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this review details the pharmacokinetic properties and profiles of ginsenosides determined in various animal models administered through different routes of administration. Such information is valuable for designing specialized delivery systems and determining optimal dosing strategies for ginsenosides. Elsevier 2019-07 2018-06-18 /pmc/articles/PMC6606970/ /pubmed/31308806 http://dx.doi.org/10.1016/j.jgr.2018.06.001 Text en © 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Review Won, Hyo-Joong Kim, Hyun Il Park, Taejun Kim, Hyeongmin Jo, Kanghee Jeon, Hyojin Ha, Seo Jun Hyun, Jung Min Jeong, Aeri Kim, Jung Sik Park, Ye Jin Eo, Yun Ho Lee, Jaehwi Non-clinical pharmacokinetic behavior of ginsenosides |
title | Non-clinical pharmacokinetic behavior of ginsenosides |
title_full | Non-clinical pharmacokinetic behavior of ginsenosides |
title_fullStr | Non-clinical pharmacokinetic behavior of ginsenosides |
title_full_unstemmed | Non-clinical pharmacokinetic behavior of ginsenosides |
title_short | Non-clinical pharmacokinetic behavior of ginsenosides |
title_sort | non-clinical pharmacokinetic behavior of ginsenosides |
topic | Short Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606970/ https://www.ncbi.nlm.nih.gov/pubmed/31308806 http://dx.doi.org/10.1016/j.jgr.2018.06.001 |
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