RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs

A gene delivery system that allows efficient and safe stem cell modification is critical for next-generation stem cell therapies. An RNA virus-based episomal vector (REVec) is a gene transfer system developed based on Borna disease virus (BoDV), which facilitates persistent intranuclear RNA transgen...

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Detalles Bibliográficos
Autores principales: Komatsu, Yumiko, Takeuchi, Dan, Tokunaga, Tomoya, Sakurai, Hidetoshi, Makino, Akiko, Honda, Tomoyuki, Ikeda, Yasuhiro, Tomonaga, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606997/
https://www.ncbi.nlm.nih.gov/pubmed/31309127
http://dx.doi.org/10.1016/j.omtm.2019.05.010

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