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Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance
PURPOSE: Clinical significance of cardiac biomarkers response in ultra-endurance runners are not completely elucidated because events vary in distance/duration and competitors modulate running intensity according to individual running capacity. The aim of this study was to examine the relationship b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607063/ https://www.ncbi.nlm.nih.gov/pubmed/31338451 http://dx.doi.org/10.1016/j.heliyon.2019.e01913 |
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author | Hohl, Rodrigo Nazário de Rezende, Fernando Millet, Guillaume Y. Ribeiro da Mota, Gustavo Marocolo, Moacir |
author_facet | Hohl, Rodrigo Nazário de Rezende, Fernando Millet, Guillaume Y. Ribeiro da Mota, Gustavo Marocolo, Moacir |
author_sort | Hohl, Rodrigo |
collection | PubMed |
description | PURPOSE: Clinical significance of cardiac biomarkers response in ultra-endurance runners are not completely elucidated because events vary in distance/duration and competitors modulate running intensity according to individual running capacity. The aim of this study was to examine the relationship between self-selected exercise intensity with cardiac biomarkers comparing experienced (EXP, N = 11) and novice (NOV, N = 14) runners able to finish a 24h ultramarathon (24UM) with significant differences in performance. METHODS: Cardiac biomarkers (i.e. CKMB/totalCK, cTnT and NT-proBNP), inflammatory markers (i.e. leukocytes and CRP) and cortisol were analyzed before and after a 24UM. RESULTS: EXP finished the race with significant (p < 0.05) longer distance than NOV (158.8 ± 15.8 vs 116.8 ± 10.3 Km). Two-way mixed ANOVA showed significant time × performance level interaction with greater increase of cTnT (F(1,23) = 6.18, p = 0.021), NT-proBNP (F(1,23) = 9.27, p = 0.006) and cortisol (F(1, 23) = 5.13, p = 0.03) in the EXP group. CKMB/totalCK (F(1, 23) = 71.90, p < 0.0001) decreased while leukocytes (F(1, 23) = 100.06, p < 0.0001) and CRP (F(1, 23) = 93.37, p < 0.0001) increased in both groups (main effect of time). Correlations were found between 24UM distance and cortisol (r = 0.58; p = 0.002), CKMB (r = 0.47; p = 0.017), cTnT (r = 0.44; p = 0.027) or NT-proBNP (r = 0.56; p = 0.003). Cortisol and NT-proBNP were also significantly correlated (r = 0.51; p = 0.01). CONCLUSIONS: Although there is no clear evidence of cardiac risk when comparing cardiac biomarkers levels with clinical cut-off values, cardiac biomarkers are associated with running performance and pituitary-adrenocortical system response. In EXP runners, higher levels of cardiac biomarkers and cortisol suggest a more hemodynamically challenged heart during prolonged endurance exercise. |
format | Online Article Text |
id | pubmed-6607063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66070632019-07-23 Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance Hohl, Rodrigo Nazário de Rezende, Fernando Millet, Guillaume Y. Ribeiro da Mota, Gustavo Marocolo, Moacir Heliyon Article PURPOSE: Clinical significance of cardiac biomarkers response in ultra-endurance runners are not completely elucidated because events vary in distance/duration and competitors modulate running intensity according to individual running capacity. The aim of this study was to examine the relationship between self-selected exercise intensity with cardiac biomarkers comparing experienced (EXP, N = 11) and novice (NOV, N = 14) runners able to finish a 24h ultramarathon (24UM) with significant differences in performance. METHODS: Cardiac biomarkers (i.e. CKMB/totalCK, cTnT and NT-proBNP), inflammatory markers (i.e. leukocytes and CRP) and cortisol were analyzed before and after a 24UM. RESULTS: EXP finished the race with significant (p < 0.05) longer distance than NOV (158.8 ± 15.8 vs 116.8 ± 10.3 Km). Two-way mixed ANOVA showed significant time × performance level interaction with greater increase of cTnT (F(1,23) = 6.18, p = 0.021), NT-proBNP (F(1,23) = 9.27, p = 0.006) and cortisol (F(1, 23) = 5.13, p = 0.03) in the EXP group. CKMB/totalCK (F(1, 23) = 71.90, p < 0.0001) decreased while leukocytes (F(1, 23) = 100.06, p < 0.0001) and CRP (F(1, 23) = 93.37, p < 0.0001) increased in both groups (main effect of time). Correlations were found between 24UM distance and cortisol (r = 0.58; p = 0.002), CKMB (r = 0.47; p = 0.017), cTnT (r = 0.44; p = 0.027) or NT-proBNP (r = 0.56; p = 0.003). Cortisol and NT-proBNP were also significantly correlated (r = 0.51; p = 0.01). CONCLUSIONS: Although there is no clear evidence of cardiac risk when comparing cardiac biomarkers levels with clinical cut-off values, cardiac biomarkers are associated with running performance and pituitary-adrenocortical system response. In EXP runners, higher levels of cardiac biomarkers and cortisol suggest a more hemodynamically challenged heart during prolonged endurance exercise. Elsevier 2019-06-27 /pmc/articles/PMC6607063/ /pubmed/31338451 http://dx.doi.org/10.1016/j.heliyon.2019.e01913 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Hohl, Rodrigo Nazário de Rezende, Fernando Millet, Guillaume Y. Ribeiro da Mota, Gustavo Marocolo, Moacir Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title | Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title_full | Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title_fullStr | Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title_full_unstemmed | Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title_short | Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
title_sort | blood cardiac biomarkers responses are associated with 24 h ultramarathon performance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607063/ https://www.ncbi.nlm.nih.gov/pubmed/31338451 http://dx.doi.org/10.1016/j.heliyon.2019.e01913 |
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